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rformed independently three times at least. doi:10.1371/journal.pone.0055615.gOverexpression of bKlotho Suppresses Tumor FormationTo determine whether bKlotho was involved in tumorgenesis, we further examined the effect of bKlotho on tumorgenesis in vivo using a xenograft mouse model. Hepatoma cells were transfected with vector or bKlotho, and then injected subcutaneously into nude mice to initiat

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