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Tin StructureFigure 6. Lack of POF results in large-scale changes in HP1a and H3K9me2/3 and demonstrates that HP1a on chromosome four consists of POF-dependent and -independent pools. A. Mutations in POF alter H3K9me2, H3K9me3 and HP1a enrichment on chromosome four. Enrichment levels (M-values) are shown for H3K9me2, H3K9me3, and HP1a on chromosome 4 (left) and in pericentric heterochromatin (prop

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