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Which are surface exposed and contiguous, defining an extended but overlapping version of the binding site (Fig. 6B). Three of the four remaining residues, C216 and C231 forming the C-terminal most disulfide bridge, plus E228 at the calcium cage, are also surface exposed at one end of the convex face and appear to constitute a prolongation of the known binding site (Fig. 6B). Only D227 is buried.

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