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Tion, and return home healthy.John D Grabenstein deputy director Military Vaccine Agency, 5113 Leesburg Pike, Suite 402, Falls Church, VA 22041 USA john.grabenstein@us.army.mil William Winkenwerder Jr assistant secretary of defense (health affairs) Washington, DC, USA5 Eckart RE, Love SS, Atwood JE, Arness MK, Cassimatis DC, Campbell CL, et al. Incidence and follow-up of inflammatory cardiac comp
Ay, and the inhibition of ALDH1-mediated retinoid signaling impairs human fetal islet cell differentiation and survival [5]. It is also known that cancer stem cells share features of normal stem cells. Therefore, it can't be excluded in the ovarian cancer cells that ALDH1 exerts its role through the same molecular mechanism, by such contributing to the better survival in ovarian cancers, although
Sion and Negative groups (p < 0.05, Kaplan-Meier). b High expression level of ALDH1 in tumor cells in ovarian carcinomas was significantly associated with high PFS probabilities (p < 0.05, Kaplan-Meier). c The expression level of ALDH1 in the stromal cells in ovarian carcinoma had no significant association with OS probabilities (p > 0.05, Kaplan-Meier). d No statistical association was found bet
Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman
A badly reported 1950s trial of a vaccine similar to adsorbed anthrax vaccine (AVA). This vaccine was probably effective against cutaneous anthrax but the researchers specifically concluded that no such claims could be made regarding inhalation anthrax. The Institute of Medicine report cited by Winkenwerder and Grabenstein concludes that such evidence exists as follows: "Finding: The committee fi
Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman
He University of Texas MD Anderson Cancer Center. In their long-term follow-up study, The same mouse monoclonal anti-human ALDH Clone 44 from BD Transduction LaboratoriesTM was used, and it turned out that high level of ALDH1 was detected in 19 out of the total 442 ovarian carcinoma samples, and it was significantly associated with endometrioid adenocarcinoma, early-stage tumor, complete respon
Ovary [38], indicating a possibly different role of ALDH1 in ovarian cancer. Our present immunohistochemical study of 248 wellcharacterized patients showed high levels of ALDH1 expression in ovarian carcinoma cells, which were observed in 15.7 of the total cases, was associated with early-stage tumor, well-differentiated tumor and better survivals, although ALDH1 was not an independent risk fac
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